In life, we often hear some proverbs that seem exaggerated but contain profound truths, and "cephalosporin with wine, just go" is one of them. This seemingly joking sentence is actually related to the safety of our lives. But even so, there are still people who ignore it and put their health on the brink of danger.

Xiaoqiang, who is 23 years old this year, is such a young man who "does not believe in evil". He has a cheerful personality and is full of vitality, and he especially likes to have a few drinks with his friends on weekdays to enjoy the relaxation and comfort brought by the drunkenness. However, a recent experience has made him deeply appreciate the cruel reality behind this proverb.

Not long ago, Xiaoqiang accidentally caught a cold, and his physical discomfort made him a little upset. In order to recover his health as soon as possible, he went to the doctor, and after careful examination, the doctor prescribed him some cephalosporins and repeatedly told him: "Don't drink alcohol while taking the medicine, this is not a joke!" Xiaoqiang agreed at the time, but he didn't take it too seriously.

One day, a group of friends met for a party, and the lively atmosphere and the warm invitation of friends made Xiaoqiang throw the doctor's advice out of the clouds. As usual, he drank as much as he did with his friends and enjoyed the happy hour of the party. After the party, Xiaoqiang, who returned to the dormitory, did not realize the danger he was about to face. As he usually does, he picked up the cephalosporin prescribed by the doctor and ate a few.

Just 120 minutes later, something terrible happened. Xiao Qiang suddenly felt a strong discomfort, the scene in front of him became blurry, his head began to dizzy, nausea welled up in his heart, and even hallucinations. Immediately afterward, his body became weaker and weaker, and he eventually fell into a state of acute shock. Luckily, my roommate was in the next room at the time, and I hurried over to check on the movement when I heard the movement. Seeing Xiaoqiang's critical condition, the roommates did not hesitate at all and immediately dialed 0 emergency number. After the full rescue of the medical staff, Xiaoqiang picked up a life from the hands of death.

"Cephalosporin with wine, just go", is it scientific or alarmist?

"Cephalosporin with wine, just go", this widely circulated phrase is not groundless alarmism, but has a rigorous scientific principle.

The main ingredient of the alcohol we drink daily is ethanol. When we drink alcohol, the alcohol is quickly absorbed through the gastrointestinal tract into the bloodstream, where it circulates through the body and eventually reaches the liver. In the liver, the "human chemical factory", ethanol is gradually metabolized into acetaldehyde under the action of alcohol dehydrogenase. Acetaldehyde is a substance that is toxic to the human body, but under normal circumstances, it will continue to be metabolized into acetic acid under the further action of acetaldehyde dehydrogenase, and finally decomposed into water and carbon dioxide, which is excreted through breathing and urine.

However, when we take cephalosporins in the process, the situation becomes complicated. When cephalosporins enter the body, there is a high probability that they will trigger a disulfiram reaction. Disulfiram was originally used to stop drinking, and when combined with ethanol, it inhibits the metabolic function of acetaldehyde dehydrogenase in the liver. This is like setting a barrier for the metabolic path of acetaldehyde, so that acetaldehyde can not continue to decompose and oxidize, so as to accumulate a large amount in the body. The accumulation of acetaldehyde can lead to body poisoning, and patients will experience a series of uncomfortable symptoms, such as nausea, vomiting, palpitation, facial flushing, and increased heart rate. More severely, this toxic reaction may also cause myocardial infarction, respiratory depression, acute heart failure, and even death.

However, not all cephalosporins trigger a disulfiram reaction. This mainly depends on the chemical structure of the drug. Cephalosporin drugs containing methiotetrazolium groups in their chemical structure, such as cefmondol, cefnicesi, cefpiramide, cefoperazone, etc., can easily cause disulfiram-like reactions; Although ceftriaxone and ceftazidime do not have a side chain of methiohydroazole, they contain a side chain of methiotriazine, and there is also the possibility of triggering a disulfiram-like reaction; However, cefradine and cefuroxime ester have neither methiotetrazolium side chain nor methiotriazine side chains, and the risk of disulfiram-like reactions is relatively small.

Will there be a difference between "post-alcohol cephalosporin" and "post-cephalosporin"?

Many people know that they can't drink alcohol after eating cephalosporin, but the difference between "post-alcohol cephalosporin" and "post-cephalosporin wine" is not very clear. What's the difference between the two? How long should I be drinking alcohol after eating cephalosporin? How long does it take to eat cephalosporin after drinking?

In fact, whether you eat cephalosporin first and drink alcohol after drinking alcohol, or drink alcohol before cephalosporin, it is possible to trigger a disulfiram-like reaction. And as for how long after eating cephalosporin, and how long after drinking can I eat cephalosporin, it mainly depends on the duration of the disulfiram-like reaction.

The onset time of disulfiram-like reactions varies from person to person, most of them occur within 1 -0 minutes after taking the drug, but there are also cases where disulfiram-like reactions occur after an interval of 0 hours or even within 0 weeks of drinking. Moreover, whether it is pre-alcohol or after-drinking, the chance of seizures within a week is the highest.

It is important to note that the severity of symptoms of disulfiram-like reactions is directly proportional to the amount of medication taken, the amount of alcohol consumed, and the duration of alcohol consumption. In other words, the more medications you take, the more alcohol you drink, and the closer you drink to the time you take them, the more severe your symptoms are likely to be. In addition, an individual's metabolic capacity can also have an impact on the severity of the disulfiram-like reaction. Generally speaking, disulfiram-like reactions with mild symptoms can recover on their own by resting, drinking plenty of water, etc.; However, if the symptoms are severe, it is necessary to seek medical attention in time to avoid life-threatening conditions.

To ensure safety, it is generally recommended that if cephalosporin is eaten first, it is best to wait 3 - 0 days before drinking alcohol; And if you drink alcohol first, it is recommended to take cephalosporin after day 0. At these two points in time, in general, the drug and alcohol have been basically metabolized, which can minimize the risk of disulfiram-like reactions.

In addition to cephalosporin, you can't get alcohol when taking these 6 medicines

In addition to cephalosporins and alcohol, it is also necessary to strictly avoid alcohol when taking the following drugs.

Antihypertensive drugs: common antihypertensive drugs are beneficial to hemolevel, nifedipine, captopril, etc. While these drugs have a hypotensive effect, if taken with alcohol, they can easily lead to excessive vasodilation, which can lead to hypotension. Severe hypotension can lead to shock, which can be life-threatening. Imagine a sudden and drastic drop in blood pressure and a lack of adequate blood supply to the various organs of the body.

Hypoglycemic drugs: common hypoglycemic drugs such as metformin and rosiglitazone, drinking alcohol while taking the drug will increase insulin secretion. Too much insulin can cause blood sugar to drop rapidly, triggering symptoms of hypoglycemia. In addition, alcohol consumption may also increase the risk of lactic acidosis, causing patients to experience nausea, weakness and other uncomfortable symptoms. For diabetic patients, blood sugar stability is crucial, and this blood sugar fluctuation caused by alcohol consumption is undoubtedly worse.

Antipyretic analgesics: antipyretic and analgesic drugs such as aspirin and paracetamol will themselves irritate and damage the gastric mucosa. Alcohol will also cause damage to the gastric mucosa, when the two meet, it will produce a superposition effect of "2 + 0> 0", which greatly increases the probability of gastric ulcer and gastric bleeding. The stomach is an important organ for us to digest food, and if it is severely damaged, it will not only affect our diet and nutrient absorption, but may also lead to other more serious health problems.

Antidepressants: Both antidepressants and alcohol consumption can slow down the central nervous system, affecting brain function and thinking ability. When these two are combined, it can further reduce one's judgment and even lead to worsening of the condition. For patients who are struggling with depression, it is crucial to maintain the normal functioning of the brain and clear thinking, and drinking alcohol will undoubtedly bring more obstacles to their path to recovery.

Drugs for the treatment of arthritis: Naproxen, Voltarin and other common drugs for the treatment of arthritis, when combined with alcohol, are easy to cause gastric bleeding, gastric ulcers and liver damage. Arthritis patients themselves need to take long-term medication to relieve pain and control the condition, and the interaction between drugs and alcohol will not only increase the burden on the body, but also may affect the treatment effect, making the condition more difficult.

Sedative-hypnotic drugs: Sedative-hypnotic drugs such as phenobarbital, diazepam, and diazepam will have an inhibitory effect on the brain. Drinking alcohol while taking these drugs causes the brain to absorb the drugs faster and metabolize them less. This is like putting a "shackle" on the brain, making it inhibited for a long time, thus inducing severe drowsiness, dizziness and other symptoms. In this case, it will not only affect our daily life and work, but may also bring some unexpected risks.

In our daily lives, we must keep in mind these contraindications for medication and drinking. Drugs are our "weapons" against disease, and alcohol can be the "enemy" of health at some point. Strictly avoiding alcohol while taking the drug is responsible for your own health. Let's stay vigilant at all times, stay away from the "dangerous game" of medicine and alcohol, and protect our health.

Proofread by Zhuang Wu